RESUMEN
La morfea superficial es una variante rara de morfea que se distingue de la clásica tanto en la clínica como en la histopatología. Se caracteriza por máculas hipopigmentadas o hiperpigmentadas, con mínima o ninguna induración, sin síntomas asociados, contractura ni atrofia. En la histopatología, se observa un compromiso limitado a las fibras colágenas en la dermis reticular superficial. Se comunica el caso de una paciente con diagnóstico de morfea superficial tratada con fototerapia ultravioleta B y metotrexato.
Superficial morphea is a rare variant of morphea that is distinguished from the classic variant both clinically and histopathologically. It is characterized by hypo or hyperpigmented patches with minimal to no induration, without associated symptoms, without contracture or atrophy. At the histopathological level, a limited involvement of collagen fibers is observed at the level of the uperficial reticular dermis. The case of a patient with superficial morphea treated with ultraviolet B phototherapy and methotrexate is presented.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Fototerapia/métodos , Esclerodermia Localizada/terapia , Esclerodermia Localizada/diagnóstico , Esclerodermia Localizada/tratamiento farmacológico , Metotrexato/administración & dosificación , Dermis/patología , Ácido Fólico/administración & dosificaciónRESUMEN
Abstract We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
Asunto(s)
Humanos , Masculino , Anciano , Lobomicosis/diagnóstico , Lobomicosis/patología , Queloide/diagnóstico , Queloide/patología , Dermatosis de la Pierna/diagnóstico , Dermatosis de la Pierna/patología , Biopsia , Dermis/microbiología , Dermis/patologíaRESUMEN
Abstract Pseudoxanthoma elasticum-like papillary dermal elastolysis is an acquired elastic tissue disorder clinically similar to pseudoxanthoma elasticum in the absence of systemic involvement. Histopathologically, special staining of elastic fibers demonstrates a total or partial band-like loss of elastic fibers in the papillary dermis. Although ultraviolet radiation seems to be one of the main etiological factors in this entity, we report a case of pseudoxanthoma elasticum-like papillary dermal elastolysis on the neck of a woman who wore hijab.
Asunto(s)
Humanos , Femenino , Anciano , Seudoxantoma Elástico/patología , Dermis/patología , Tejido Elástico/patología , Biopsia , DermoscopíaRESUMEN
Abstract White fibrous papulosis of the neck is a rare entity, with fewer than 50 cases described. It is a benign pathology whose main interest lies in its broad differential diagnosis, especially with pseudoxanthoma elasticum. The authors report the case of a 77-year-old woman with multiple yellow-white monomorphic papules on the posterior cervical region, with years of evolution. Cutaneous biopsy revealed a nodular area in the superficial and middle reticular dermis, with slight thickening of the collagen fibers and focally enlarged elastic fibers, aspects highlighted in the Verhoeff staining that additionally showed absence of elastic fibers in the papillary dermis.
Asunto(s)
Humanos , Femenino , Anciano , Enfermedades Cutáneas Papuloescamosas/patología , Cuello/patología , Biopsia , Fibrosis , Dermis/patología , Tejido Elástico/patologíaRESUMEN
Abstract A 28-year-old white female patient presented with multiple erythematous-to-violaceous, painful, suppurative nodules on the buttocks and thighs that appeared after two weeks of mesotherapy with deoxycholate, caffeine, sunflower liposomes, and sinetrol for localized fat. She was treated for atypical mycobacteriosis, but with no satisfactory response after antibiotic therapy. Bacterial, mycobacterial, and fungal culture were all negative. Histopathologic examination of the biopsy showed noninfectious suppurative panniculitis. It resolved after treatment with methotrexate, prednisone, and hydroxychloroquine. This report highlights the rarity of this complication, the importance of its early recognition, and differentiation with atypical fast growing mycobacterioses.
Asunto(s)
Humanos , Femenino , Adulto , Paniculitis Nodular no Supurativa/inducido químicamente , Paniculitis Nodular no Supurativa/patología , Ácido Desoxicólico/efectos adversos , Mesoterapia/efectos adversos , Biopsia , Paniculitis Nodular no Supurativa/tratamiento farmacológico , Resultado del Tratamiento , Dermis/patologíaRESUMEN
Abstract: Atrophoderma of Pasini and Pierini is a skin disorder affecting dermal collagen and is clinically characterized by well-defined plaques of depressed skin. Histopathological changes are subtle, and in most cases, the diagnosis requires a comparative study with healthy skin from the same anatomical site. High frequency ultrasound is a useful imaging method for diagnosis of atrophic skin changes. A case is presented in which ultrasound can support the clinical and the histopathological diagnosis of atrophoderma of Pasini and Pierini.
Asunto(s)
Humanos , Femenino , Adulto , Enfermedades de la Piel/patología , Enfermedades de la Piel/diagnóstico por imagen , Ultrasonografía Doppler en Color/métodos , Dermis/patología , Dermis/diagnóstico por imagen , Atrofia/patología , Atrofia/diagnóstico por imagen , Biopsia , Diagnóstico PrecozRESUMEN
Abstract: Dermatofibroma is a proliferation of spindle cells located in the dermis. We used scanning electron microscopy to examine two histologically confirmed lesions and observed preserved collagen bundles in the perilesional area. In the lesional area, the collagen was denser, without formation of bundles. Higher magnification showed collagen with mesh-like appearance similar to stretched tufts of cotton. Very high magnification evidenced the tufts of cotton and spindle cells measuring 2 to 12 microns.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Neoplasias Cutáneas/patología , Histiocitoma Fibroso Benigno/patología , Microscopía Electrónica de Rastreo , Dermis/patologíaAsunto(s)
Humanos , Femenino , Adulto , Enfermedad de Fox-Fordyce/patología , Axila/patología , Vulva/patología , Biopsia , Folículo Piloso/patología , Dermis/patologíaAsunto(s)
Humanos , Femenino , Persona de Mediana Edad , Neoplasias Cutáneas/tratamiento farmacológico , Corticoesteroides/uso terapéutico , Lipomatosis/tratamiento farmacológico , Nevo/tratamiento farmacológico , Neoplasias Cutáneas/patología , Biopsia , Administración Cutánea , Resultado del Tratamiento , Dermis/patología , Lipomatosis/patología , Nevo/patologíaAsunto(s)
Humanos , Masculino , Femenino , Adulto , Adulto Joven , Leishmaniasis Cutánea/patología , Población Urbana , Biopsia , Brasil , Ciudades , Dermis/patología , Eritema/parasitología , Eritema/patología , Geografía MédicaAsunto(s)
Humanos , Femenino , Anciano , Seudoxantoma Elástico/patología , Tejido Elástico/patología , Biopsia , Dermis/patología , DermoscopíaAsunto(s)
Humanos , Femenino , Adulto , Enfermedad de Lyme/patología , Enfermedades Cutáneas Bacterianas/patología , Borrelia burgdorferi , Mordeduras de Garrapatas/patología , Enfermedades Transmisibles Importadas/patología , Biopsia , Brasil/etnología , Enfermedad de Lyme/tratamiento farmacológico , Resultado del Tratamiento , Enfermedades Cutáneas Bacterianas/tratamiento farmacológico , Dermis/patología , Eritema/microbiología , Eritema/patología , Mordeduras de Garrapatas/tratamiento farmacológico , Enfermedades Transmisibles Importadas/tratamiento farmacológico , AlemaniaRESUMEN
Abstract: Amyloidosis cutis dyschromica is a rare type of primary cutaneous amyloidosis characterized by reticulate hyper-pigmentation with discrete hypopigmented macules. Up to date, about 50 cases of amyloidosis cutis dyschromica have been reported and the majority are familial cases of Asian ethnicity. Various diseases, particularly autoimmune diseases such as systemic sclerosis and systemic lupus erythematosus, have been associated with amyloidosis cutis dyschromica. Herein, we report a case of amyloidosis cutis dyschromica accompanying familial Mediterranean fever with a delayed diagnosis of 40 years. To the best of our knowledge, this is the first report of the association of amyloidosis cutis dyschromica and familial mediterranean fever.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Fiebre Mediterránea Familiar/complicaciones , Enfermedades Cutáneas Genéticas/complicaciones , Enfermedades Cutáneas Genéticas/patología , Amiloidosis Familiar/complicaciones , Amiloidosis Familiar/patología , Biopsia , Hiperpigmentación/patología , Dermis/patologíaRESUMEN
Abstract Numerous infectious, inflammatory and neoplastic complications secondary to tattoo placement have been reported in the literature. Within inflammatory complications sarcoidal granulomatous reactions have been described. We report two cases, a 55-year-old woman with yellowish infiltrated plaques on bilateral ciliary region, 16 years after the placement of a permanent tattoo in the eyebrows, and a 20-year-old tattoo artist who developed orange papules on 3 of his tattoos. Histopathology in both cases confirmed diagnosis of sarcoidal granulomatous reaction due to tattoo pigment.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Tatuaje/efectos adversos , Dermatitis/etiología , Dermatitis/patología , Granuloma/etiología , Granuloma/patología , Sarcoidosis/etiología , Sarcoidosis/patología , Dermis/patología , CejasAsunto(s)
Humanos , Masculino , Anciano , Dedos/patología , Gota/patología , Dermatosis de la Mano/patología , Biopsia , Dermis/patologíaRESUMEN
Abstract Scleromyxedema or lichen myxedematosus is a rare papular mucinosis of chronic and progressive course and unknown etiology. It is commonly associated with monoclonal gammopathy and may show extracutaneous manifestations, affecting the heart, lung, kidney, and nerves. The diagnosis is based on four criteria: generalized papular and sclerodermoid lesions; mucin deposition, fibroblast proliferation, and fibrosis in the histopathology; monoclonal gammopathy; and no thyroid disorders. This article reports the case of a scleromyxedema patient with a recent history of acute myocardial infarction and monoclonal gammopathy.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Dermis/patología , Escleromixedema/patología , Proliferación Celular , Fibroblastos/patología , MucinasRESUMEN
Abstract Pruritic folliculitis of pregnancy is a rare disease of unknown etiology. It occcurs primarily during pregnancy, usually with spontaneous resolution postpartum. It is characterized by a benign dermatosis, with papular and pustular follicular lesions that first appear on the torso and occasionally spread throughout the body. We report the case of a patient in the 27th week of pregnancy, with a two-month evolution of pruritic and papular erythematous lesions on her lower back. Differential diagnosis includes other pregnancy-specific dermatoses: gestational pemphigoid, pruritic urticarial papules and plaques of pregnancy (PUPPP), prurigo of pregnancy, and (PUPPP) and prurigo of pregancy. Histopathological tests showed changes consistent with pruritic folliculitis of pregnancy. This case is relevant due to its rare nature and its clinical and histopathological characteristics.
Asunto(s)
Humanos , Femenino , Adulto , Complicaciones del Embarazo/patología , Prurito/patología , Foliculitis/patología , Prurigo/patología , Embarazo , Dermis/patología , Diagnóstico DiferencialRESUMEN
Abstract Wolf's isotopic response designates the appearance of two subsequent unrelated dermatoses in the same anatomic location. We report the case of a 51-year-old man with a medical history of chronic lymphocytic leukemia without known extra-hematopoietic involvement. The patient developed a disseminated papulo-vesiculous eruption, diagnosed as varicella. Few days after recovering, an erythematous and violaceous papular dermatosis with histopathological examination compatible with leukemic infiltration appeared on the scars of previous herpetic lesions. Complete remission was obtained under systemic corticotherapy, without cutaneous recurrence or blastic transformation. Wolf's isotopic response is attributed to a localized immunologic imbalance following a certain stimulus. In this patient, herpetic infection acted as a local spur for inaugural cutaneous leukemic infiltration, with no impact on the prognosis for the underlying disease.